Vitamin K2 MK-7 CAS 2124-57-4 | 99% Food Grade Menaquinone-7 – Baisfu

What the compound is

Vitamin K2 (menaquinone-7, MK-7, CAS 2124-57-4) is a fat-soluble vitamin of the menaquinone series with a seven-unit isoprenoid side chain. MK-7 has a markedly longer plasma half-life than vitamin K1 or MK-4, which is why bone-health and cardiovascular formulators specify MK-7 rather than a generic “vitamin K2”. Baisifu supplies food-grade MK-7 at 99 percent assay for bone-health, calcium-direction and women’s midlife formulations, with the all-trans isomer ratio released on every COA.

Production and origin

The material is produced by fermentation of Bacillus subtilis natto in a controlled broth, followed by extraction, purification and crystallisation. The fermentation route gives the all-trans configuration; chemically synthesised MK-7 often contains a cis fraction that has little vitamin activity, which is why the isomer ratio rather than the headline assay is the specification that matters. The Statement of Origin records the fermentation batch and the manufacturing site.

Identity and assay

MK-7 is assayed by HPLC at 248 nm against a menaquinone-7 reference standard. The standard grade is 99 percent on the dried basis with all-trans MK-7 not less than 98 percent of the total menaquinone. The COA reports MK-6 and MK-8 as related substances, the cis-isomer content, loss on drying and the residual solvents from the purification step.

Physical behaviour

MK-7 is a yellow to orange-yellow crystalline powder, practically insoluble in water and soluble in fats and oils; it is sensitive to light, particularly ultraviolet light, and should be handled away from direct sunlight. The melting range is broad (approximately 54 degrees Celsius), and the material is stable in dry powder form when protected from light and oxygen.

Applications

Vitamin K2 MK-7 enters the following formulation workflows:

• bone-health capsules and tablets, typically combined with calcium and vitamin D
• calcium-direction and vascular-health research formulations
• women’s midlife and post-menopausal bone-support products
• softgel multi-vitamin and healthy-ageing blends
• functional-food and dairy prototypes (oil-dispersible grade)

Formulation notes

MK-7 is used at microgram doses, so the practical challenge is uniform distribution rather than solubility: use a trituration or a spray-dried carrier grade for tablets and capsules, and an oil-soluble grade for softgels and emulsions. Keep the material out of direct light during blending and filling, and avoid co-processing with strong oxidisers. In calcium combinations, the usual architecture is MK-7 with calcium citrate or lactate plus vitamin D3, with the MK-7 declared as menaquinone-7 on the label.

Certificate of Analysis

Each lot ships with a COA recording:

• MK-7 assay by HPLC (dry basis)
• all-trans isomer ratio and cis-isomer content
• MK-6 and MK-8 related substances
• heavy metals (Pb, As, Cd, Hg) and residual solvents
• microbial count with specified pathogens
• loss on drying and sieve analysis

Regulatory and handling

Vitamin K2 MK-7 is supplied as a food-grade raw material for nutraceutical and functional-food formulation. It is not a drug and makes no drug-level claim. Buyers are responsible for confirming the permitted use level in the target market, and should note that vitamin K interacts with anticoagulant therapy — label warnings are the brand owner’s responsibility. Handle as a fine powder with gloves and eye protection, away from direct light.

Packaging and storage

Supplied in double-sealed food-grade polyethylene bags within fibreboard drums, 1 kg, 5 kg and 25 kg net. Store in the original sealed container at room temperature, dry, protected from light; the retest date is 24 months from manufacture when stored as recommended.

Questions

What is the difference between MK-4 and MK-7?

MK-4 has a four-unit side chain and a short plasma half-life; MK-7 has seven units and circulates considerably longer, which is why bone-health formulations specify MK-7.

Why does the trans-isomer ratio matter?

Only the all-trans form has full vitamin K activity. A 99 percent assay can still hide a significant cis fraction, so the isomer ratio belongs in the specification.

Can MK-7 be combined with calcium in one tablet?

Yes, and it commonly is. Use a triturated MK-7 grade for content uniformity, and confirm the stability of both actives in your own accelerated study rather than relying on the raw-material COA alone.

Request a quotation

Send Baisfu the required assay, isomer specification and quantity, and the sales desk will reply with a current price, the lot fingerprint, packing option and lead time, with pre-shipment samples from the quoted lot.