Soy Isoflavones 40% | Genistein and Daidzein Standardised Extract – Baisfu

What the compound is

Soy isoflavones are the phytoestrogen fraction of the soybean (Glycine max), built on three aglycones — genistein (CAS 446-72-0), daidzein (CAS 486-66-8) and glycitein — together with their glycosides genistin, daidzin and glycitin. The commercial extract is standardised to 20 percent or 40 percent total isoflavones by HPLC and is the workhorse base of non-hormonal menopause, bone-health and women’s midlife formulations worldwide, usually paired with red clover when a formulator wants two different isoflavone profiles in the same blend.

Botanical source and production

The raw material is soybean germ or soy molasses, both of which concentrate the isoflavone fraction. Baisifu extracts with aqueous ethanol, concentrates and purifies the isoflavone fraction on resin, and standardises the finished powder to the target total isoflavone content. The Statement of Origin records the soybean origin and whether the material derives from conventional or identity-preserved non-GMO lots; buyers requiring a non-GMO declaration should state it in the enquiry, because the two supply chains are contracted separately.

Identity and assay

Soy isoflavones are assayed by HPLC against genistein, daidzein and glycitein reference standards, and the result is expressed as total isoflavones on the dried basis, with the individual aglycone and glycoside distribution reported. This distribution matters commercially: the glycoside-rich form is the natural composition of the bean, while the aglycone-rich form (“enzyme-treated”) is more readily absorbed and is what most premium menopause products specify. The COA states which form is supplied and the ratio of the three markers.

Physical behaviour

The extract is a light yellow to brownish-yellow fine powder with a faint beany odour. It disperses in water with slight turbidity and is soluble in aqueous ethanol; the aglycones are less water-soluble than the glycosides. The powder is hygroscopic and tends to cake, so keep it sealed and use a glidant in dry blends.

Applications

Soy isoflavones enter the following formulation workflows:

• menopause-support capsules and tablets (non-hormonal positioning)
• bone-health and women’s midlife formulations with calcium and vitamin K2
• phytoestrogen research blends with red clover, puerarin and chasteberry
• functional-food and beverage prototypes (aglycone grades disperse better)
• cosmetic actives for mature-skin care (research grade)

Formulation notes

Two decisions shape the formulation: glycoside versus aglycone, and total isoflavone content. The aglycone form costs more but absorbs faster and is easier to justify on a label; the glycoside form is closer to the traditional food matrix and cheaper per kilogram. Typical commercial architecture is 40 to 80 mg total isoflavones per daily dose, often combined with 20 to 40 mg of a 2.5 percent black cohosh extract and with calcium and MK-7 in a bone-positioned product. Avoid co-formulating with strongly alkaline excipients, which degrade the aglycones.

Certificate of Analysis

Each lot ships with a COA recording:

• total isoflavones by HPLC with genistein, daidzein and glycitein split
• aglycone / glycoside ratio (form declaration)
• identification by HPLC retention time and UV spectrum
• loss on drying, ash and heavy metals (Pb, As, Cd, Hg)
• residual solvents and microbial count with specified pathogens
• sieve analysis and bulk density

Regulatory and handling

Soy isoflavones are supplied as a botanical raw material for nutraceutical and functional-food formulation. They are not a drug and make no drug-level claim. Soy is a declared allergen in several markets, so the finished-product labelling is the brand owner’s responsibility. Handle as a fine powder with gloves and eye protection.

Packaging and storage

Supplied in double-sealed food-grade polyethylene bags within fibreboard drums, 1 kg, 5 kg and 25 kg net. Store in the original sealed container at room temperature, dry, protected from light; the retest date is 24 months from manufacture when stored as recommended.

Questions

What is the difference between glycoside and aglycone soy isoflavones?

The glycoside form carries a sugar unit (genistin, daidzin) and matches the natural bean composition; the aglycone form (genistein, daidzein) has the sugar removed, absorbs more readily and is what most premium menopause products specify.

How does soy compare with red clover?

Soy is dominated by genistein and daidzein glycosides, while red clover is dominated by the methylated aglycones biochanin A and formononetin. Formulators often use both to widen the isoflavone profile.

Can you supply non-GMO material?

Yes, from identity-preserved soybean lots, with a written non-GMO declaration. State the requirement in the enquiry because the non-GMO chain is contracted and priced separately.

Request a quotation

Send Baisfu the required total isoflavone content, aglycone or glycoside form and quantity, and the sales desk will reply with a current price, the lot fingerprint, packing option and lead time, with pre-shipment samples from the quoted lot.